https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 Common variants in breast cancer risk loci predispose to distinct tumor subtypes https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44999 Wed 26 Oct 2022 10:12:59 AEDT ]]> Chronic obstructive pulmonary disease and lung cancer: Underlying pathophysiology and new therapeutic modalities https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36606 Wed 17 Nov 2021 16:31:32 AEDT ]]> Cumulative small effect genetic markers and the risk of colorectal cancer in Poland, Estonia, Lithuania, and Latvia https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:28485 Wed 11 Apr 2018 14:12:51 AEST ]]> European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation. https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53962 Tue 23 Jan 2024 12:39:27 AEDT ]]> Exploring the genetics of irritable bowel syndrome: a GWA study in the general population and replication in multinational case-control cohorts https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:26934 KDELR2 (KDEL endoplasmic reticulum protein retention receptor 2) and GRID2IP (glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein), showed consistent IBS risk effects in the index GWAS and all replication cohorts and reached p=9.31×10-6 in a meta-analysis of all datasets. Several SNPs in this region are associated with cis effects on KDELR2 expression, and a trend for increased mucosal KDLER2 mRNA expression was observed in IBS cases compared with controls. Conclusions: Our results demonstrate that general population-based studies combined with analyses of patient cohorts provide good opportunities for gene discovery in IBS. The 7p22.1 and other risk signals detected in this study constitute a good starting platform for hypothesis testing in future functional investigations.]]> Sat 24 Mar 2018 07:27:31 AEDT ]]>